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7. Bacterial diseases
tetanus vaccine IM
C hild ren and ad ults: 0 .5 m l/ injectio n
W ith no vaccinatio n o r unk no wn vaccinatio n status: ad m inister at least 2 d o ses at an
interval o f 4 week s.
W ith inco m p lete vaccinatio n: ad m inister o ne d o se.
T hen, to ensure lo ng- lasting p ro tectio n, ad m inister ad d itio nal d o ses to co m p lete th e
to tal 5 d o ses, as ind icated in the table belo w.
human anti-tetanus immunoglobulin IM
C hild ren and ad ults: 2 5 0 I U as a single d o se; 5 0 0 IU fo r wo und s m o re than 2 4 ho urs
o ld .
Inject the vaccine and the im m uno glo bulin in 2 d ifferent sites, using a sep arate sy ringe
fo r each.
2) Routine vaccination (pre-exposure prophylaxis)
– C hild ren: 5 d o ses in to tal: a first series o f 3 d o ses o f D T P o r D T P + H ep B o r
D TP +
tHheibag+e oHf e6p, 1B0 baenfod r1e 4thewaegeek os),f t1heyneaar4, addmo sineisotefreadvaactcainneinctoernvtaalinoinf g1 temtanousnttho(xeo.gi.d
baet tween the ages o f 4 to 7 y ears, then a 5 d o se between 1 2 and 1 5 y ears.
th
th
(d T o r T T ) with an interval o f at least o ne m o nth between the 1 and 2 d o se and an
– Winteorvmal oefnaot lfecahsitld6bemariongntahgseb: e5twdeoensethsed2uringanthde3repdroo sdeu,cthtiveen ytweoarso: tahesrerdieossoesf ,3each
d o ses
st nd
nd rd
at m inim um interval o f o ne y ear, e.g. d uring p regnancies (see table belo w).
– P regnant wo m en: if a wo m an has never been vaccinated o rriefdhuecr evathcecinriastkioonfstteattaunsuiss7in
unk no wn: 2 d o ses o f d T o rT T d uring the p regnancy to
m o ther and newbo rn: the first as so o n as p o ssible d uring the p regnancy and the
seco nd
at least 4 week s later and at least 2 week s befo re d elivery . T his vaccinatio n regim e
p ro tects m o re than 8 0 % o f newbo rns fro m neo natal tetanus. A single d o se o ffers
no
p ro tectio n. C o ntinue vaccinatio n after d elivery to co m p lete 5 d o ses, as fo r wo m en
To fV 1 No p ro tectio n
child bearing age.
DToVse2 A t leVaastcc4inwateioenk sscahfetedruTle Vin a1dults Degree and duration of protection
T V 3 O n first co ntact with the health care sy stem 80%
o r as so o n as p o ssible d uring p regnancy 1 to 3 y ears
TV 4 95%
5 y ears
T V 5 6 m o nths to 1 y ear after T V 2
o r d uring the fo llo wing p regnancy 99%
1 to 5 y ears after T V 3 1 0 y ears
o r d uring the fo llo wing p regnancy
1 to 1 0 y ears after T V 4 99%
o r d uring the fo llo wing p regnancy T hro ugho ut the rep ro d uctive y ears
3) Other measures
A p p ro p riate hy giene d uring d elivery , includ ing ho m e birth.
tetanus vaccine IM
C hild ren and ad ults: 0 .5 m l/ injectio n
W ith no vaccinatio n o r unk no wn vaccinatio n status: ad m inister at least 2 d o ses at an
interval o f 4 week s.
W ith inco m p lete vaccinatio n: ad m inister o ne d o se.
T hen, to ensure lo ng- lasting p ro tectio n, ad m inister ad d itio nal d o ses to co m p lete th e
to tal 5 d o ses, as ind icated in the table belo w.
human anti-tetanus immunoglobulin IM
C hild ren and ad ults: 2 5 0 I U as a single d o se; 5 0 0 IU fo r wo und s m o re than 2 4 ho urs
o ld .
Inject the vaccine and the im m uno glo bulin in 2 d ifferent sites, using a sep arate sy ringe
fo r each.
2) Routine vaccination (pre-exposure prophylaxis)
– C hild ren: 5 d o ses in to tal: a first series o f 3 d o ses o f D T P o r D T P + H ep B o r
D TP +
tHheibag+e oHf e6p, 1B0 baenfod r1e 4thewaegeek os),f t1heyneaar4, addmo sineisotefreadvaactcainneinctoernvtaalinoinf g1 temtanousnttho(xeo.gi.d
baet tween the ages o f 4 to 7 y ears, then a 5 d o se between 1 2 and 1 5 y ears.
th
th
(d T o r T T ) with an interval o f at least o ne m o nth between the 1 and 2 d o se and an
– Winteorvmal oefnaot lfecahsitld6bemariongntahgseb: e5twdeoensethsed2uringanthde3repdroo sdeu,cthtiveen ytweoarso: tahesrerdieossoesf ,3each
d o ses
st nd
nd rd
at m inim um interval o f o ne y ear, e.g. d uring p regnancies (see table belo w).
– P regnant wo m en: if a wo m an has never been vaccinated o rriefdhuecr evathcecinriastkioonfstteattaunsuiss7in
unk no wn: 2 d o ses o f d T o rT T d uring the p regnancy to
m o ther and newbo rn: the first as so o n as p o ssible d uring the p regnancy and the
seco nd
at least 4 week s later and at least 2 week s befo re d elivery . T his vaccinatio n regim e
p ro tects m o re than 8 0 % o f newbo rns fro m neo natal tetanus. A single d o se o ffers
no
p ro tectio n. C o ntinue vaccinatio n after d elivery to co m p lete 5 d o ses, as fo r wo m en
To fV 1 No p ro tectio n
child bearing age.
DToVse2 A t leVaastcc4inwateioenk sscahfetedruTle Vin a1dults Degree and duration of protection
T V 3 O n first co ntact with the health care sy stem 80%
o r as so o n as p o ssible d uring p regnancy 1 to 3 y ears
TV 4 95%
5 y ears
T V 5 6 m o nths to 1 y ear after T V 2
o r d uring the fo llo wing p regnancy 99%
1 to 5 y ears after T V 3 1 0 y ears
o r d uring the fo llo wing p regnancy
1 to 1 0 y ears after T V 4 99%
o r d uring the fo llo wing p regnancy T hro ugho ut the rep ro d uctive y ears
3) Other measures
A p p ro p riate hy giene d uring d elivery , includ ing ho m e birth.
